中文
Short name：MYO
Detection method: Latex enhanced immunoturbidimetry
Packaging specifications：Various
①: The product packaging is suitable for mainstream models such as Hitachi, Abbott, Siemens, Roche, Beckman, Toshiba, Deere, Mindray, Kehua and so on.
②: High sensitivity, high specificity and strong anti-interference ability.
Clinical Significance
MYO is a 153-amino acid polypeptide chain and a ferrous heme protein consisting of a ferric heme subgroup found in skeletal and cardiac tissues. Due to its relatively small molecular weight, myoglobin can be quickly released from ischemic myocardial tissue into human blood. After the onset of myocardial infarction, the blood concentration of myoglobin rises rapidly at 1-3h, reaching the peak at 6-7h, and almost all patients with myocardial infarction have increased myoglobin within 12h. Moreover, due to the short half-life of myoglobin, no increase of 6-12h after the onset of chest pain can exclude myocardial infarction, which is also a good indicator of myocardial infarction. Myoglobin can be removed from the kidney and fully restored to normal levels within 18 to 30h of onset. So myoglobin measurement can be helpful to observe the presence or absence of reinfarction during the course of myocardial infarction. The elevation and duration of serum myoglobin in patients with myocardial infarction were significantly positively correlated with the infarct area and the degree of myocardial necrosis. Generally, the elevation of serum myoglobin in patients with subendocardial and large area infarction lasted for 3-4d. If serum myoglobin does not decrease or increases, or if serum myoglobin decreases and then increases abnormally, the infarction continues to expand, myocardial necrosis worsens, or new infarction occurs. Because of the high sensitivity of myoglobin in the diagnosis of myocardial infarction, the early determination of myoglobin has certain reference value for the early diagnosis of myocardial infarction.
Inspecting Principle
The method is enhanced immunoturbidimetry. Monoclonal and polyclonal antibodies are bound to latex granules, and the tested antigen in the patient's serum (or calibration) binds to the antibody on the latex surface in the buffer, cross-linking the latex granules with each other and increasing the turbidity of the solution. Within a certain range, the turbidity of the reaction liquid is linearly correlated with the amount of the measured antigen.
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